By the team at L’Atelier Aesthetics, checked by Dr Duncan Brennand, Lead Aesthetic Doctor, 101 Harley Street
Profhilo is the most frequently booked treatment at L’Atelier Aesthetics, and for patients coming to it for the first time, the experience itself is often the unknown part. The treatment is well documented. The step-by-step reality of the appointment, the days that follow and the timeline of results is less consistently explained.
This guide sets out exactly what a Profhilo appointment at 101 Harley Street involves – from the consultation through to the weeks afterwards – in more detail than most clinics provide.
A Profhilo appointment begins with a consultation with Dr Brennand, followed on the same day or at a later date by a short injection session. A full course is two sessions four weeks apart. Downtime is minimal – small raised bumps at the injection sites for up to 24 hours and occasional light bruising. The skin quality improvement builds progressively over six to eight weeks after the second session.
Profhilo is a high-concentration injectable skin booster that, once placed, spreads through the surrounding tissue rather than remaining at the point of injection. Five injection points on each side of the face can therefore improve a considerably wider area of the face over the following weeks.
The immediate effect is improved hydration and a visible improvement in radiance, typically apparent within one to two weeks. The firming and skin quality improvement develops from week four onwards, reaching its best at around two months after the second session. Results last six to nine months, with a single maintenance session every six months sustaining the benefit.
Profhilo is appropriate for most patients from their mid-thirties onwards whose primary concern is skin quality, hydration, mild firmness or crepey texture. It is a particularly suitable first injectable treatment for patients new to aesthetics, because it improves the condition of the skin without changing the shape of the face.
It can be used on the face, neck, decolletage and hands, and works well for patients noticing early softening along the jawline alongside a general decline in skin quality.
Profhilo is not the appropriate treatment where:
The concern is volume loss in a specific area – a hollow under the eye, thin lips or deflated cheeks. These require dermal filler.
The patient is pregnant or breastfeeding.
There is an active skin infection in the treatment area.
Certain autoimmune conditions are present and active.
Dr Brennand will confirm suitability and identify any relevant contraindications at consultation.
| Stage | What happens |
|---|---|
| Before the appointment | Avoid blood-thinning supplements and non-essential anti-inflammatories for one week. Skip alcohol for 24 hours. Arrive with a clean face. |
| The consultation | Around 30 minutes with Dr Brennand. He reviews your medical and skin history, assesses your face in natural light, and proposes a plan. Treatment can often be carried out the same day. |
| The injection | Ten to fourteen minutes in total. Five specific points on each side of the face. Most patients describe each point as a brief sting that settles within seconds. |
| Immediately after | Five small raised bumps on each side, settling within 24 hours. Makeup can go back on the following morning. Most patients return to work the same day or the next. |
| Weeks 1 to 2 | Hydration and an early glow appear. |
| Weeks 4 onwards | Firming and skin quality improvement builds, with the full result showing around two months after the second session. |
| Second session | Four weeks after the first, following the same process without the full consultation. |
For the first 24 hours: avoid strenuous exercise, saunas, steam rooms and swimming. Do not massage the injection points. Avoid applying makeup directly over the injection sites on the first evening.
For the first 48 hours: pause active skincare ingredients such as retinol and exfoliating acids.
For the first week: apply sunscreen consistently and avoid prolonged direct sun exposure on the treated area.
Any bruising typically resolves within three to five days.
“Profhilo is the treatment I recommend most often to first-time patients because it does what almost everyone wants from aesthetic medicine – it makes the skin look like a better-rested version of itself, without changing the face. Done properly, a two-session course produces a visibly improved skin quality that lasts the better part of a year.”
Dr Duncan Brennand, Lead Aesthetic Doctor, L’Atelier Aesthetics
At L’Atelier Aesthetics, every Profhilo injection is delivered personally by Dr Brennand. Planning, dosing and placement all sit with the doctor.
L’Atelier Aesthetics is a doctor-led clinic at 101 Harley Street, London. Every Profhilo treatment begins with a clinical consultation with Dr Duncan Brennand, who assesses the skin, confirms suitability and determines whether Profhilo is the most appropriate treatment or whether a combination approach would serve the patient better.
Dr Brennand is a GMC-registered aesthetic doctor with over a decade of experience on Harley Street. His GMC reference number is 4341662, verifiable on the GMC medical register.
The clinic is at 101 Harley Street, London W1G 6AH, a short walk from Bond Street and Oxford Circus underground stations.
Profhilo is delivered in two sessions four weeks apart. Each session takes around 15 minutes. The first session is preceded by a consultation with Dr Brennand to confirm the plan and ensure Profhilo is the right fit.
Hydration and an early glow appear within one to two weeks. The deeper firming and skin quality improvement builds over six to eight weeks, with the best result around two months after the second session.
Most patients describe each injection point as a brief sting that settles within seconds. A numbing cream is available for patients who prefer it, though most do not need it.
Downtime is minimal. Small raised bumps at the injection points settle within 24 hours. Occasional light bruising clears within up to five days. Makeup can be applied the morning after treatment.
Results typically last six to nine months after a full two-session course. A single maintenance session every six months keeps the benefit going.
Profhilo is priced as a two-session course, which is how the treatment is designed to be used. Maintenance sessions are charged separately. Pricing is discussed openly at consultation.
We welcome patients from across Marylebone, Mayfair, Fitzrovia, Regent’s Park, Soho, Knightsbridge, Belgravia, Chelsea and Kensington, as well as visitors travelling to London for specialist aesthetic and skin treatments. Our location benefits from excellent transport links, with Oxford Circus only a 13 minute walk away, Bond Street and Regent’s Park Underground stations are also both within easy reach. The clinic is also conveniently accessible from major London rail stations and Heathrow, Gatwick and London City airports thanks to the Elizabeth line, making visits straightforward for both UK and international patients.
Whether you are travelling from within London or further afield, our Harley Street clinic provides a calm, professional environment for personalised aesthetic and skin health treatments in one of the capital’s most respected medical locations.
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