Restore radiance, smooth fine lines, and deeply rejuvenate your complexion with Polynucleotides at our Harley Street clinic in Marylebone.
Polynucleotides are naturally derived, purified DNA molecules that trigger the body’s own cell renewal and tissue repair processes. When injected into the skin, they act as powerful bio-stimulators, encouraging fibroblasts to produce new collagen, elastin, and hyaluronic acid, while improving oxygenation and hydration.
Unlike treatments that mask imperfections, Polynucleotides promote true skin regeneration, delivering natural-looking, long-term improvements in tone, texture, and resilience. It’s the definition of undetectable rejuvenation.
This results in stronger, firmer, and more luminous skin over time. They’re suitable for all skin types and ages, making them a versatile solution for early signs of ageing or general skin revitalisation.
Polynucleotides work by creating a rejuvenating microenvironment within the skin. Once injected, they stimulate fibroblast activity which is the key cells responsible for producing structural proteins like collagen and elastin.
The results:
As Polynucleotides regenerate rather than fill, the outcome is a gradual, authentic improvement rather than a sudden or “overdone” change.
The under-eye area is one of the most delicate parts of the face, prone to thin skin, fine lines, and dark shadows. Polynucleotides under eyes are one of the most sought-after treatments at our Harley Street clinic, helping to:
Because the treatment works with your body’s natural healing processes, it achieves a refreshed look that remains soft and authentic.
At L’Atelier, we combine medical precision with aesthetic artistry. Every Polynucleotide treatment is performed by Dr Duncan Brennand, who brings deep expertise in facial anatomy and regenerative techniques.
Our approach includes:
We prioritise subtle, gradual enhancement, not overcorrection. Our ethos is built on honesty, integrity, and patient confidence.
Our ethos at L’Atelier Aesthetics is built around subtle rejuvenation and clinical expertise. We provide a calm, private environment where each patient receives a bespoke treatment plan focused on natural results and overall skin health. Every procedure is carried out by Dr Duncan Brennand, ensuring the highest level of safety and precision.
If you still have questions about Polynucleotides, or would like to speak to a member of the team. You can contact us by; Phone, Email, WhatsApp and WebForm. It is our upmost priority that during your stay at 101 Harley Street, whether in our surgical or non surgical clinic, you feel safe, relaxed, and comfortable, so please do not hesitate to reach out to any of our highly trained team should you require anything.
Discover the regenerative power of Polynucleotides and restore your skin’s vitality with subtle, natural results.
Book your consultation at L’Atelier Aesthetics, 101 Harley Street, and experience the science of cellular renewal.
They are purified DNA molecules derived from natural sources, designed to safely stimulate skin regeneration without adding artificial volume.
You’ll start to see subtle improvements within 2–3 weeks. Full results typically develop after completing a recommended course of two sessions.
Results generally last between 6–9 months, depending on your skin type, age, and lifestyle. Maintenance treatments can prolong the regenerative effects.
They improve firmness, smoothness, and hydration by stimulating the production of collagen and elastin, while repairing damaged skin cells.
We usually recommend a course of two treatments spaced three weeks apart for optimal collagen stimulation, followed by maintenance every 6–9 months.
Yes. Polynucleotides are biocompatible and clinically tested. At L’Atelier Aesthetics, every treatment is performed by a qualified doctor in a medical environment on Harley Street.
Absolutely. Polynucleotides under the eyes are one of our most popular treatments. They help to reduce dark circles, fine lines, and crepiness while improving skin thickness and hydration, delivering a refreshed, smoother appearance without fillers.
Treatment involves minimal discomfort. Most patients describe the sensation as light pressure or a mild pinch during injection.
While skin boosters focus on hydration and fillers add volume, Polynucleotides go deeper, regenerating tissue and improving long-term skin structure.
A course every 6–9 months maintains the best results and supports ongoing skin health.
Yes. They work beautifully alongside skin boosters, microneedling, or energy-based treatments such as Sofwave or Morpheus8 for complete skin rejuvenation.
Mild redness or small bumps may appear immediately after treatment, resolving within 24 hours. There’s no significant downtime and you can return to normal activities the same day.
Dr Duncan Brennand is our lead Aesthetic Physician at L’Atelier with a wealth of expertise in both innovative and evidence-based treatments. He is an expert in all things Polynucleotides, dermal fillers, HA injections, collagen stimulating fillers and our skin booster ranges, along with many other non surgical and surgical treatments.
We are delighted to have over 200+ 5 star reviews. Your feedback is always important to us, as it helps us to improve our systems and processes in our continual pursuit of excellence. If you have any suggestions, comments, or concerns please get in touch.
Our clinic is located on Harley Street in Marylebone, London, one of the world’s most prestigious and historic medical districts. Situated within 101 Harley Street, our clinic offers a discreet and refined setting in the heart of Central London, renowned for its concentration of leading medical and aesthetic specialists.
We welcome patients from across Marylebone, Mayfair, Fitzrovia, Regent’s Park, Soho, Knightsbridge, Belgravia, Chelsea and Kensington, as well as visitors travelling to London for specialist aesthetic and skin treatments.
Our location benefits from excellent transport links, with Oxford Circus, Bond Street and Regent’s Park Underground stations all within easy reach. The clinic is also conveniently accessible from major London rail stations and Heathrow, Gatwick and London City airports, making visits straightforward for both UK and international patients.
Whether you are travelling from within London or further afield, our Harley Street clinic provides a calm, professional environment for personalised aesthetic and skin health treatments in one of the capital’s most respected medical locations.
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