Julaine at L’Atelier Aesthetics, 101 Harley Street with Dr Duncan Brennand, this innovative collagen-stimulating injectable rejuvenates skin from within for natural, long-lasting results.
Performed exclusively by our lead aesthetic doctor, Dr Duncan Brennand, Julaine at our Harley Street clinic is the new era of injectable rejuvenation. Designed for those seeking subtle, natural transformation rather than volume, it restores your skin’s radiance by awakening its own collagen.
We are thrilled to announce that the innovative Julaine injectable treatment is available at L’Atelier Aesthetics with Dr Duncan Brennand. If you want to learn more about this exciting treatment that is designed to be a ‘skin bio-activator’, or in simple terms, a treatment to naturally reactive your body’s own collagen, explore below and reach out to specialist L’Atelier team.
What is Julaine?
Julaine at our 101 Harley Street clinic a bio-stimulating injectable derived from advanced poly-L-lactic acid (PLLA) technology. Once injected, it works deep within the dermis to activate your skin’s natural collagen production, improving texture, elasticity, and firmness gradually over time. Unlike hyaluronic acid fillers that provide instant volume, Julaine focuses on long-term skin rejuvenation that lasts up to two years without the inflammatory effects that can be caused by other products such as Sculptra.
Julaine’s key benefits include:
Stimulates collagen for firmer, smoother skin
Restores natural facial contours and volume
Improves texture, tone, and elasticity
Subtle, progressive results that enhance over time
Long-lasting outcomes with minimal downtime
Harley Street expertise: Treatments are led by Dr Duncan Brennand, known for his precision technique and natural results.
Medical excellence: Our Harley Street clinic operates to the highest clinical standards in safety and care.
Tailored consultation: Every Julaine plan is individually designed to enhance your skin’s natural structure and tone.
Discreet, luxury setting: L’Atelier Aesthetics offers a calm, professional environment with personalised patient care.
When it comes to collagen-stimulating or bio-stimulating injectable treatments, Julaine and Sculptra are often compared as both treatments are powered by poly-L-lactic acid (PLLA), a material that is widely known thanks to Sculptra which has been available for over 25 years. What sets Julaine apart is its advanced LaSynPro™ technology, which ensures greater uniformity of the microspheres injected into the skin. What does this mean? More predictable results, and improved comfort during treatment. Julaine is designed for precise placement and even collagen regeneration, this is why its essential to consult an expert like Dr Duncan Brennand for your collagen injection treatment. So whilst Sculptra paved the way for biostimulation and still continues to be an extremely safe and effective treatment, Julaine represents an exciting new alternative for our patients looking for a treatment that provides results that are authentic and real.
Your Julaine questions answered. If you still have questions about Julaine, or would like to speak to a member of the team you can reach out to us below. It is our upmost priority that during your stay at 101 Harley Street, whether in our surgical or non surgical clinic, you feel safe, relaxed, and comfortable, so please do not hesitate to reach out to any of our highly trained team should you require anything.
Julaine is a collagen-stimulating injectable that improves skin texture, firmness, and radiance by activating natural collagen production in the deeper layers of the skin.
Common side effects include mild redness, swelling, small bumps, or bruising at the injection site. These usually resolve within a few hours to a few days.
Both Julaine and Sculptra are PLLA-based collagen stimulators designed to boost natural collagen. However, Julaine has been developed using next-generation purification and particle technology to offer a smoother injection experience, faster preparation, and greater precision. Many patients report a more comfortable treatment and a refined, natural finish. Remember with all treatments at L’Atelier we will insist upon a thorough consultation, to ensure the treatment is tailored to your needs.
No. Julaine is a biostimulator, not a filler. It doesn’t add instant volume, instead it triggers your skin to regenerate collagen gradually, enhancing structure and elasticity over time.
Yes, both are collagen stimulators, they support your body to produce new natural collagen. However, Julaine uses an enhanced formulation of PLLA designed for improved precision, consistency, and comfort with its LaSynPro™ technology . This process is anti / non-inflammatory approach thanks to its innovative formulation compared to Sculptra that produces an inflammatory response to stimulate your body’s own collagen.
Collagen stimulation begins gradually, with results becoming visible within 6–12 weeks after treatment, however you may start to see improvements in skin quality quicker then this.
Julaine results can last up to 24 months, depending on your skin and treatment plan.
No, Julaine isn’t a traditional HA or Dermal filler. Unlike hyaluronic acid (HA) fillers that provide instant volume, Julaine stimulates your body’s own collagen to improve structure over time.
Typically 2–3 sessions are recommended, spaced 4–6 weeks apart, for optimal collagen stimulation and longevity. Many common treatment areas include the cheeks, jawline, temples, and lower face to restore lift and contour.
At our L’Atelier Aesthetics clinic at 101 Harley Street, Marylebone, we charge from £1000* for Julaine treatments. A single treatment will cost from £1200 whilst a course of 3 treatments will cost £3000. Again all treatments are subject to a consultation, if you want to learn more about our pricing please speak to the team.
*Based on a course of 3 treatments for £3000. 1 treatment from £1200. Subject to a thorough consultation.
No, although both use Poly-L-lactic (PLLA) acid to stimulate collagen, Julaine features next-generation LaSynPro™ technology for smoother integration and more even results. We have found Julaine easier to inject and, as a result, more consistent in its treatment outcomes. Its refined particle design helps achieve natural-looking outcomes with greater comfort and predictability.
Significant or rapid weight loss, including that associated with GLP-1 medications such as Ozempic, Wegovy or Mounjaro, can lead to noticeable changes in facial structure. Commonly referred to as “Ozempic face”, this typically presents as volume loss in the mid-to-lower face, deepening of nasolabial folds, increased marionette lines and reduced skin firmness.
While weight loss improves overall health, the reduction in facial fat and soft tissue support can leave the face appearing more hollow, tired or prematurely aged.
At L’Atelier Aesthetics on Harley Street, we approach this concern by focusing on structural restoration and collagen regeneration rather than simply replacing lost volume.
When facial volume changes rapidly, the skin’s underlying collagen framework can appear diminished. Traditional dermal fillers can restore volume instantly, but in cases of weight-loss related facial change, a collagen stimulating treatment offers a more regenerative approach.
Julaine, a poly-L-lactic acid skin bio-activator, works by gradually encouraging the body’s own collagen production. Rather than creating immediate fullness, it helps rebuild the skin’s structural integrity over time, improving firmness, definition and skin quality.
This progressive approach is particularly suited to patients who:
Have developed deeper nasolabial folds following weight loss
Notice increased marionette lines or lower face laxity
Feel their mid-face appears hollow or deflated
Wish to avoid an overfilled or artificial appearance
Facial volume loss caused by rapid weight reduction does not typically reverse on its own once weight has stabilised. While skin quality may improve slightly over time, deeper structural changes often require professional treatment to restore support and definition.
Collagen stimulating injectables help address this by:
Gradually strengthening the skin’s collagen matrix
Softening folds and creases
Improving skin firmness and elasticity
Restoring natural facial proportions
Because results develop progressively over several weeks, the outcome appears subtle, refined and entirely natural.
At L’Atelier Aesthetics, treatments are delivered by the team under the guidance of Dr Duncan Brennand, with careful assessment of facial balance, tissue quality and long-term goals.
For patients experiencing facial changes following weight loss or GLP-1 medication use, collagen stimulation can be an excellent option for restoring structure without heaviness. Results can last up to 18 to 24 months depending on individual response and treatment plan. If you are also considering GLP-1s as part of an on-going treatment plan, you can consult with The Wright Practice also based at 101 Harley Street. Their team will be able to advise the best course of treatment depending on your individual needs.
If you are concerned about changes in facial volume after weight loss, a personalised consultation at our Harley Street clinic will determine the most appropriate and natural approach for you.
Dr Duncan Brennand, Medical Director at L’Atelier Aesthetics, is a highly experienced aesthetic doctor based on Harley Street. With an extensive background in non-surgical rejuvenation and a commitment to natural outcomes, Dr Duncan is trusted for his artistry, precision, and medical integrity.
Before treatment, the skin is cleansed and a numbing cream or local anaesthetic is applied to ensure complete comfort. Julaine is then prepared for precise, even injection using advanced micro-cannula techniques to minimise bruising and optimise results.
The Julaine treatment generally takes 30 minutes, during which small amounts of Julaine are placed strategically beneath the skin. Julaine’s unique LASYNPRO technology, using highly uniform microspheres, stimulates the body’s own collagen to gradually restore structure, firmness, and luminosity.
There’s minimal downtime, you may experience light swelling or redness for 24–48 hours. Dr Brennand will provide detailed aftercare guidance, including gentle massage techniques to ensure smooth, even distribution.
As your skin’s own collagen gradually regenerates, fine lines soften, contours re-emerge, and luminosity returns without the look or feel of traditional filler.
Results develop progressively over 6–12 weeks, revealing firmer, smoother skin with authentic radiance. The photographs below demonstrate the natural improvement achieved after one or two sessions, reflecting the subtle yet transformative effect of Julaine when performed by an experienced practitioner like Dr Brennand.
Following Julaine treatment at L’Atelier Aesthetics in Harley Street, mild swelling, redness or bruising may occur and typically settles within a few days. As a poly-L-lactic acid collagen bio-activator, Julaine works gradually by stimulating natural collagen production, with visible improvements developing over 8 to 12 weeks. Most patients return to normal activities the same day, although excessive heat, UV exposure and strenuous exercise should be avoided for 24 hours.
Julaine is a next generation PLLA-based skin bio-activator designed to naturally reactivate your body’s collagen production for long-lasting and authentic facial rejuvenation. Unlike traditional dermal fillers that provide immediate volume, Julaine restores structure progressively by encouraging your skin to rebuild its own collagen framework.
Because of this regenerative mechanism, recovery is typically minimal and results develop gradually over time.
Immediately After Your Julaine Treatment
After your appointment at our Harley Street clinic, you may notice:
These effects are common and usually resolve within several days.
Some temporary fullness may also be visible due to the injection process. This settles as swelling reduces and collagen stimulation begins.
To help minimise swelling or bruising, a cold compress can be applied gently to the treated area. Ice packs should not be placed directly onto the skin.
Massage Guidance
In the days following treatment, you may be advised to perform a light circular massage using your usual facial moisturiser. If recommended, this should be done gently and only as instructed during your consultation.
Massage guidance can vary depending on your treatment plan, so always follow the specific advice provided by the L’Atelier team.
What to Avoid After Julaine
For the first 24 hours:
Until any initial redness or swelling has resolved:
If you are planning laser resurfacing, chemical peels or other treatments that stimulate an active dermal response, please consult the L’Atelier team before scheduling these either before or after your Julaine treatment.
When Will I See Results from Julaine?
Julaine works by gradually stimulating collagen regeneration.
Because Julaine enhances your natural collagen structure, results appear refined and subtle, improving skin quality, firmness and facial definition over time.
How Long Do Julaine Results Last?
As a PLLA collagen stimulator, Julaine can deliver long-lasting improvements in skin firmness and structure. Results may last up to 18 to 24 months depending on your treatment plan and individual response.
A course of treatments may be recommended to optimise collagen regeneration and maintain results.
When to Contact Us
Julaine is delivered by the L’Atelier Aesthetics team under the guidance of Dr Duncan Brennand.
Mild swelling, redness or tenderness are expected following treatment and usually settle within a few days. However, if you experience symptoms that feel unusual, persist longer than expected or cause concern, we encourage you to contact our Harley Street clinic for personalised advice.
This may include:
Your comfort, safety and results are always our priority. If you are unsure about anything following your Julaine treatment, please get in touch so we can support and reassure you appropriately.
We are delighted to have over 200+ 5 star reviews. Your feedback is always important to us, as it helps us to improve our systems and processes in our continual pursuit of excellence. If you have any suggestions, comments, or concerns please get in touch.
Our clinic is located on Harley Street in Marylebone, London, one of the world’s most prestigious and historic medical districts. Situated within 101 Harley Street, our clinic offers a discreet and refined setting in the heart of Central London, renowned for its concentration of leading medical and aesthetic specialists.
We welcome patients from across Marylebone, Mayfair, Fitzrovia, Regent’s Park, Soho, Knightsbridge, Belgravia, Chelsea and Kensington, as well as visitors travelling to London for specialist aesthetic and skin treatments.
Our location benefits from excellent transport links, with Oxford Circus, Bond Street and Regent’s Park Underground stations all within easy reach. The clinic is also conveniently accessible from major London rail stations and Heathrow, Gatwick and London City airports, making visits straightforward for both UK and international patients.
Whether you are travelling from within London or further afield, our Harley Street clinic provides a calm, professional environment for personalised aesthetic and skin health treatments in one of the capital’s most respected medical locations.
